Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic,epigenomic,and transcriptomic profiling in paired primary tumor and PVTT samples

【作者】 杨扬； Lei Chen； Jin Gu； Hanshuo Zhang； Jiapei Yuan； Hongyang Wang； Michael Q.Zhang； Zhi John Lu；

【Author】 Yang Yang;Lei Chen;Jin Gu;Hanshuo Zhang;Jiapei Yuan;Hongyang Wang;Michael Q.Zhang;Zhi John Lu;School of Life Sciences,Tsinghua University;Eastern Hepatobiliary Surgery Institute,Second Military Medical University;Bioinformatics Division,TNLIST and Department of Automation,Tsinghua University;

【机构】 清华大学； Eastern Hepatobiliary Surgery Institute,Second Military Medical University； Bioinformatics Division,TNLIST and Department of Automation,Tsinghua University；

【摘要】 <正>Hepatocellular carcinoma(HCC)is highly potent to invade the portal venous system and subsequently develop into the portal vein tumor thrombosis(PVTT).PVTT could induce intra-hepatic metastasis,which is closely associated with poor prognosis.A comprehensive systematic characterization of long noncoding RNAs(lncRNAs)更多还原