【作者】 张小玲； 隋丽； 孔福全；

【Author】 ZHANG Xiao-ling;SUI Li;KONG Fu-quan;Department of Nuclear Physics,China Institute of Atomic Energy;

【机构】 中国原子能科学研究院核物理研究所；

【摘要】 ~7Li离子属于高LET辐射,是辐射生物学基础研究中使用的重离子射线之一,它是硼中子俘获治疗癌症中起关键作用的离子。与低LET辐射相比,高LET辐射通过直接作用于生物的靶分子DNA,而诱发更为复杂、严重、不易修复的DNA损伤,如双链断裂和非双链断裂集簇性损伤等,从而引起细胞凋亡、细胞周期改变、细胞衰老和死亡、癌变和变异等生物学效应。因此,建立辐射生物学专用实验装置和相应的束流诊断方法,获得束流品质满足生物样本辐照要求的离子束,是开展~7Li离子束致生物大分子或细胞的辐射生物学效应研究的重要前提。本研究在北京HI-13串列加速器R20支线末端的生物用新终端上进行,运用不同的探测方法对串列加速器引出的43 MeV~7Li离子束流的稳定性、束斑大小和均匀性、注量的准确性进行测量和评估,实验结果表明:在4.2×10~4~1.5×10~5particles/cm~2/s注量率范围内,两种不同类型闪烁体探测器测得注量率变化呈线性关系,束流稳定性良好;均匀性好于90%的最大束斑面积为5.0 cm×5.0 cm;运用闪烁体探测器监测的~7Li离子注量与CR39固体核径迹探测器测得的绝对注量的误差小于10%。束流特性满足辐射生物学实验要求。更多还原

【Abstract】 ~7Li ions with high linear energy transfer(LET) have been used in radiobiological research,which is key particle in Boron Neutron Capture Therapy.In present study,the new terminal had been established for radiobiological application,located at the end of R20 branch beam line of HI-13 tandem accelerator.The beam qualities of ~7Li ions with the energy 43 MeV generated by HI-13 tandem accelerator,including beam stability,spot size,uniformity and particle fluence accuracy were measured using different detection methods.The results showed that the flux measured with different detectors had a good linear relationship as particle flux ranged from 4.2×10~4~1.5×10~5particles/cm~2/s,beam uniformity was over 90%at 5 cm×5 cm area,and particle fluence accuracy was better than 90%.All results showed that the beam qualities of ~7Li ions finely met the basic requirements for radiation biological experiment.更多还原