辛伐他汀对急性肺栓塞兔炎细胞因子的影响

【作者】 杨永； 张艳敏； 梁明亭； 骆峰； 武蕾； 李义波；

【机构】 山东省聊城市人民医院；

【摘要】 目的探讨辛伐他汀对急性肺血栓栓塞症兔血清肿瘤坏死因子-α(TNF-α)及白细胞介素-1β(IL-1β)的影响。方法选用30只新西兰健康白兔,随机分为对照组、模型组、辛伐他汀干预组。采用兔自体血栓回输法建立急性肺栓塞模型。采用酶联免疫吸附法检测血清肿瘤坏死因子-α及白细胞介素-1β的浓度变化。结果栓塞后3小时,模型组TNF-α、IL-1β浓度(5.52±0.99ng/ml,183.06±30.43pg/ml)与对照组(2.16±0.63ng/ml,94.26±8.57pg/ml)、辛伐他汀干预组(4.20±0.88ng/ml,146.09±21.07 pg/ml)比较有显著统计学意义(p<0.01,p<0.01)。栓塞6小时两者浓度基本达基线水平。结论急性肺血栓栓塞后,血清TNF-α、IL-1β浓度升高;辛伐他汀可降低急性肺血栓性栓塞血清TNF-α、IL-1β水平。更多还原

【Abstract】 objective To explore the changes of serum tumor necrosis factoro(TNF-α) interleukin1β(IL-1β) and effect of simvastatin on acute pulmonary thromboembolism(APTE) rabbits.Method APTE models were established by injecting autologous blood clots into right atrium by femoral vein.30 healthy zelanian rabbits were selected and divided into the control group(n=10)(model group(n=10) and simvastatin group(n=10) randomly.The changes of TNF-α IL-1β in the blood serum were tested with an enzyme-linked immunosorbent assay(EL1SA).Result At 3 hour point after embolization.TNF-α IL-1β of model group arrived at 5.52±0.99ng/ml,183.06±30.43pg/ml which were higher in comparison with those(2.16±0.63ng/ml,94.26±8.57pg/ml and 4.20±0.88ng/ml,146.09±21.07pg/ml) in control group and simvastatin group.The values of model group were higher in comparison with the control group and the simvastatin group(P<0.01,P<0.01).Conclusion After APTE,cytokines of TNF-α IL-1β increased obviously.Simvastatin may inhibit the cytokines.After APTE,anti-inflammatory therapy may become an important treatment.更多还原