【作者】 包云； 申月云； 宋玲玲； 邹蓓蓓； 柳沁元；

【Author】 BAO Yun;SHEN Yue Yun;SONG Ling-ling;ZOU Bei Bei;LIU Qin Yuan;Department of Clinical Nutrition,Yangzhou First people’s Hospital;

【机构】 扬州市第一人民医院临床营养科；

【摘要】 目的探讨男性非酒精性脂肪肝(NAFLD)患者的人体成分、血脂以及肝功能水平的相关性。方法共纳入418名男性,其中260名诊断为NAFLD,对照组158名,根据B超将NAFLD分为轻度161名,中度65例,重度34例。采用人体成分分析仪检测各组患者体成分的变化,同时收集血清检测血脂及肝肾功能相关指标。结果轻度、中度、重度NAFLD患者与对照组相比体重、体重指数(BMI)、腹围、腰臀比、颈围、体脂百分比、内脏脂肪区域(VFA)、谷氨酰转肽酶(GGT)、甘油三酯(TG)、高密度脂蛋白-胆固醇(HDL-C)差异均有统计学意义;中度、重度NAFLD患者的谷丙转氨酶(ALT)、谷草转氨酶(AST)、空腹血糖(FBG)、尿酸(UA)与对照组相比差异有统计学意义;NAFLD的严重程度与体重、BMI、腹围、腰臀比、颈围、体脂百分比、VFA、ALT、GGT、TG、FBG、UA呈正相关;NAFLD的严重程度与HDI-C呈负相关;NAFLD的高危因素包括:FBG、TG。结论男性NAFLD患者体成分与生化指标的特征是腹型肥胖、颈围增大、内脏脂肪增多、ALT、GGT、FBG、TG水平高,HDL-C水平低,其中HDL-C是NAFLD患者的保护性因素。更多还原

【Abstract】 Objective To study the body composition,blood lipids and hepatic functions of nonalcoholic fatty liver disease(NAFLD) in males.Methods A total of 418 males were enrolled and divided into four groups by ultrasonography:normal control group(n=158),low grade NAFLD(n=161),middle grade NAFLD(n=65),high grade NAFLD(n=34).The changes of body composition were analyzed by Inbody 720.The blood lipids and hepatorenal functions were measured by biochemical analyzer.Result Body weight,body mass index(BMI),abdominal perimeter,waist hip ratio,neck circumference,body fat percentage,visceral fat area(VFA),gamma glutamyl transpeptidase(GGT),triglyceride(TG) and high density lipoprotein cholesterol(HDL-C) were significantly different between NAFLD group and control group.Alanine transaminase(ALT),glutamic oxaloacetic?transaminase(AST),fasting blood glucose(FBG)and uric acid(UA) of middle and high grade NAFLD were significantly higher than that in control group.The severity of NAFLD were positively correlated to body weight,BMI,abdominal perimeter,waist hip ratio,neck circumference,body fat percentage,VFA,ALT,GGT,TG,FBG,UA.Significant negative correlation was found between the severity of NAFLD and the level of HDL-C.FBG and TG were risk factors of NAFLD.Conclusion Male NAFLD patients manifest abdominal obesity,neck circumference increases,visceral fat increases,high level of ALT,GGT,FBG,TG,low level of HDL-C.The level of HDL-C was a protective factor of NAFLD.更多还原