【作者】 戴军有； 赵颖超； 张铎； 王伟； 毕力夫； 王睿君；

【Author】 ZHAO Yin chao;DAI Jun you;ZHANG Duo;Inner Mongolia Hospital;

【机构】 内蒙古自治区中医医院； 内蒙古自治区人民医院； 北京中医药大学； 内蒙古医科大学；

【摘要】 目的:探索血清脂联素(APN)和尿表皮生长因子(EGF)对早期糖尿病肾病(DN)的诊断价值。方法:多中心收集早期DN182例,以170例单纯糖尿病(DM)为对照,检测EGF、APN、UAER、CysC、CRP,进行统计学分析。结果:1.两组比较,上述指标差异均有统计学意义(P<0.05,P<0.01);2.相关分析显示:APN与CRP,UAER与APN、CysC、CRP均呈正相关(P<0.05),EGF与APN、UAER呈负相关(P<0.05)。结论:检测EGF、APN、CysC等指标有助于早期发现糖尿病肾病。更多还原

【Abstract】 Objectives:To explore the diagnostic value of APN and EGF in early stage diabetic nephropathy(DN).Methods:182 patients multicentric with early DN were selected as observation group(group A),while 170 patients with the Type 2 diabetes mellitus and also without diabetic complications(T2DM,group B) were took as the control.The indexes in serum or urine were detected,which were urinary epidermal growth factor(EGF)、serum adiponectin(APN),urinary albumin excretion rate(UAER)、 serum cystatin C(CysC)、 serum C reactive protein(CRP),the levels of biological indexes were analyzed by the statistical method.Result:1.There was statistical significance in all the indexes above between group A and group B(P<0.05,P<0.01);2.UAER was positively correlated with CysC、 CRP and APN(P<0.05);Positive correlation were also found between APN and CRP(P<0.05);EGF was negatively correlated with APN and UAER(P<0.05).Conclusion:Detection of EGF,APN,CysC and CRP was helpful in the early diagnosis of diabetic nephropathy.更多还原