【作者】 阳珠生； 陈飞； 何艳梅； 阳年发； 范青华；

【Author】 Zhusheng Yang;Fei Chen;Yanmei He;Nianfa Yang;Qing-Hua Fan;CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS);Key Laboratory of Environmentally Friendly chemistry of the Ministry of Education, College of Chemistry, Xiangtan University;

【机构】 中国科学院化学研究所分子识别与功能院重点实验室； 湘潭大学化学学院环境友好化学重点实验室；

【摘要】 手性四氢喹啉衍生物是构筑一系列生物活性分子的重要骨架^[1]。自周永贵小组首次报道喹啉的不对称氢化以来^[2],一系列手性膦配体金属铱络合物在有机溶剂中催化喹啉衍生物的不对称氢化见诸报道^[3]。我们以手性二胺金属钌配合物为催化剂,在纯水条件下即可实现喹啉的不对称氢化^[4],对映选择性最高达99%ee(与有机相不对称氢化结果相当^[5])。更多还原

【Abstract】 Optically pure tetrahydroquinoline derivatives are an important class of building blocks for the preparation of biologically active compounds.^[1]Since the pioneering work reported by Zhou and co-workers,^[2]a number of iridium complexes containing different types of chiral phosphorus ligands have been developed to catalyze the enantioselective hydrogenation of quinoline derivatives in organic solvents.^[3]In this presentation,we reported that chiral cationic Ru-diamine complexes could catalyze this reaction in neat water^[4]and excellent enantioselectivities were obtained（up to 99%ee）,which are comparable to those obtained in organic solvents.更多还原