【作者】 王葛阳； 韩荣弼；

【Author】 Geyang Wang;Rongbi Han;Rongbi Han Department of Chemistry,University of Yan Bian;

【机构】 延吉市长白山生物资源与功能分子教育部重点实验室延边大学；

【摘要】 桦木酸是一种羽扇烷五环三萜类化合物,具有消炎,抗病毒,抗肿瘤等功效[1]。缩氨基硫脲基团是一类含有硫酰胺键的特殊希夫碱,也具有多种生物活性如抗肿瘤、抗菌,消炎等[2]。实验室前人研究表明,部分桦木酮和桦木醛缩氨基硫脲金属配合物对革兰氏阳性菌(如S.mutans 3289型变形链球菌)和Hela癌细胞具有较强的抑制作用。我们以桦木醇为起始物,用琼斯试剂氧化成桦木酮酸,桦木酮酸与硫代氨基脲缩合得到配体,最后与金属盐进行络合,得到了2种桦木酮酸缩氨基硫脲铜(Ⅱ),钯(Ⅱ)金属配合物,并通过红外,核磁共振氢谱,差热-热重分析,飞行质谱对其结构进行了表征。此研究为桦木酸的开发利用,以及其在抗菌,抗癌活性方面的研究提供基础的理论数据。更多还原

【Abstract】 Betulinic acid is a pentacyclic triterpene,which possesses a variety of therapeutically properties including:anti-inflammatory,anti-virus,anti-tumor and other biological activities.Thiosemicarbazone group also has a variety of biological activities such as anti-tumor,anti-bacterial,anti-inflammatory.Two new betulinic acid thiosemicarbazone metal complexes were synthesized through oxidation,condensation and complexation steps using betulin as a starting material.These synthesized novel derivatives have been characterized by IR,~1H NMR,TGA,MALDI-TOF mass spectra,etc.更多还原