【作者】 徐祥； 胡敏； 马丹丹； 陈愈忠； 张志鹏；

【Author】 Xiang Xu;Min Hu;Dandan Ma;Yuzhong Chen;Zhipeng Zhang;Department of Applied Chemistry, School of Science, Xi’an Jiaotong University;

【机构】 西安交通大学理学院化学系；

【摘要】 稀土上转换发光具有光稳定性高,组织穿透深度深,信噪比大等优点,因此其在生物领域有着广阔的应用前景,而成为近年来的研究热点。本文巧妙构建具有核壳结构的Na Gd F₄:Yb³⁺,Er³⁺,Nd³⁺@Na Gd F₄:Nd³⁺（Er@Nd）稀土纳米材料,在单颗纳米材料上实现双波长激发下的三模式发光。Er@Nd在980nm的光激发下在522nm,540nm,660nm处产生NIR–Vis的上转换发光(Yb³⁺→Er³⁺),在793nm的光激发下既在522nm,540nm,660nm处产生NIR–Vis的上转换发光(Nd³⁺→Yb³⁺→Er³⁺),又在980nm,1060nm处产生NIR–NIR的下转换发光(Nd³⁺→Yb³⁺)。[1]Er@Nd的NIR–Vis上转换发光及NIR–NIR的下转换发光在第一,第二生物光学窗口处有发射,因而在组织和血液中有良好的穿透性,是一种性能优越、可提供多光学通道选择的高灵敏度荧光成像探针。同时,稀土元素的重原子效应及Gd³⁺的顺磁性,使其具有良好的CT及MRI造影能力。因此Er@Nd是一种潜在的集高灵敏度生物荧光成像、CT成像以及MR成像的多功能造影剂。通过Er@Nd的多模成像可获取更全面、准确的医学诊断信息,为肿瘤的早期诊断提供强有力的支持。[2]更多还原

【Abstract】 Upconversion luminescence with good photostability, deep penetration in tissue, high signal-to-noise ratio shows a promising picture in biology and generates a large amount of research interest. We fabricated a kind of core-shell Na Gd F₄:Yb³⁺, Er³⁺, Nd³⁺@Na Gd F4:Nd³⁺（named Er@Nd） with NIR–Vis and NIR–NIR dual-conversion luminescence. Er@Nd’s luminescence is located in the region of the I, II optical window in biological tissues allowing the minimal absorption and maximal transmission of blood and tissues which means it is a high sensitivity luminescence imaging probe with superior performance and multi-channel optical choice. What’s more, rare earth elements with heavy atom effect and Gd³⁺ with superior paramagnetic can be used as a potential contrast agent for CT Imaging and MRI. Therefore Er@Nd provides options to construct a unique platform for potential multimodal UCL/DCL/CT/MR imaging simultaneously which is able to provide more comprehensive and accurate imaging information and improve the quality and accuracy of the early diagnosis of tumor.更多还原