【作者】 聂伟； 苗莹珂； 周小军； 张彦中； 何创龙；

【Author】 Wei Nie;Yingke Miao;Xiaojun Zhou;Yanzhong Zhang;Chuanglong He;College of Chemistry,Chemical Engineering and Biotechnology,Donghua University;

【机构】 东华大学化学化工与生物工程学院；

【摘要】 近年来,二维纳米材料以其独特的物理化学性质引起人们极大的研究热情,并在新能源,光学材料,化学催化,生物医学等领域取得了很多成果。我们采用氧化石墨烯(GO)和纳米羟基磷灰石(nHA)作为前体,在一定的水热反应条件下(200℃,3h),溶液中的nHA能够自发的沉积到GO上,并且通过自组装,形成三维多孔的结构。研究发现,前体材料的配比对最终的形貌有很大的影响。电子能谱,X-射线衍射和扫描电子显微镜(SEM)的结果进一步表明,在自组装过程中,nHA首先吸附到GO上,形成GO复合溶胶,然后在水热还原反应的驱动下发生自组装,形成石墨烯复合三维多孔支支架。体内动物实验发现,复合材料能在6周内快速修复新西兰大白兔颅骨顶端4 mm的圆形缺损,并且修复部位的骨密度明显增高,说明其在新骨生成和矿化成熟方面具有良好的促进作用。更多还原

【Abstract】 Graphene have attracted increasing attention in biomedical application due to its remarkable properties such as good biocompatibility,high specific surface area and excellent electrical conductivity.In this paper,a 3D porous reduced graphene oxide(RGO) composite was prepared with graphene oxide and nano-hydroxyapatite(nHA) by self-assembly,thus constructing biomimetic scaffold for bone tissue engineering.Detailed studies were performed to evaluate its structure and in vivo bone repair efficiency,emphasizing the influences of the composite on in vivo bone cell growth and mineralization.It was demonstrated that the circular calvarial defects with 4 mm diameter in rabbit were successfully healed by nHA@RGO porous scaffold after 6 weeks implanting,which was visibly quicker than the pure RGO scaffold.These results indicated that the as-prepared porous scaffold have a promising capacity to stimulate mineralization and promote the in vivo defect healing.更多还原