【作者】 刘启昊； 严章强； 胡睿； 钟金莲； 柳辉金； 王科军； 罗序中；

【Author】 Qihao Liu;Zhangqiang Yan;Rui Hu;Jinlian Zhong;Huijin Liu;Kejun Wang;Xuzhong Luo;School of Chemistry & Chemical Engineering,Gannan Normal University;

【机构】 赣南师范学院化学化工学院；

【摘要】 设计合成了酰胺的衍生物N,N’,N’’-三(3-吡啶基)均三苯甲酰胺和N,N’,N’’-三(4-吡啶基)均三苯甲酰胺[1]。它们可以在聚乙二醇(200、300、400或600)和水混合物中形成凝胶。特别有意义的是,这种凝胶非常稳定、缓释效果好,有望在生物活体中实现缓释给药的应用[2]。利用扫描电子显微镜(SEM)、流变(RA)、X-射线衍射(XRD)等现代分析技术对该凝胶进行了分析。结果表明,凝胶剂分子自组装形成的网络结构将溶剂禁锢于这些网络结构的空隙之中,不能自由流动,从而导致物理凝胶的形成。该类凝胶的流变学测试结果都展现出较好的机械性能和典型的类固体流变学行为。更多还原

【Abstract】 The amide derivative N~1,N~3,N~5-tri(pyridin-3-yl)benzene-1,3,5-tricarboxamide and N~1,N~3,N~5-tri(pyridin-4-yl)benzene-1,3,5-tricarboxamide were designed and synthesized in this article.They can form stable gel in the mixtures of Polyethylene glycol(200,300,400 or 600) and water.It is significative to note that the gel is stable and show good release effect,which is expected to apply in controlled release of drug in vivo in the future.The gelations have been systematically characterized by SEM、RA、SA-XRD and so on.The results show that the network structure formed by molecular self-assembled will immobilize the liquids,leading to the formation of physical gel.The gel rheological test results have shown good mechanical properties and rheological behavior of a typical kind of solid.更多还原