【作者】 钱科宏； 奚菊群； 范磊； 郭荣；

【Author】 Kehong Qian;Juqun Xi;Lei Fan;Rong Guo;Chemical Engineering,Yangzhou University;

【机构】 扬州大学化学化工学院；

【摘要】 金纳米粒子的高热能积聚性能可以增强高强度聚焦超声（HIFU）的消融效率,是一种较好的HIFU增效剂。本实验使用简便而有效的水/油/水（W/O/W）乳液的方法制取PLGA混合纳米囊,在弱碱性含水环境下通过多巴胺的自聚合形成PDA/PLGA纳米囊。随后加入氯金酸（HAuCl₄）溶液,AuCl₄^-离子被PDA分子吸附至PDA/PLGA纳米囊的表面,并还原成纳米金颗粒形成AuNPs@PDA/PLGA纳米囊。实验结果表明,所得AuNPs@PDA/PLGA纳米囊具有体外增强超声能力和增强HIFU消融牛肝的治疗作用,是一种潜在的HIFU增效剂。更多还原

【Abstract】 Herein,we present a simple method to prepare Au-nanoparticles coated polydopamine modified poly（lactic-co-glycolic acid）（AuNPs@PDA/PLGA） hybrid capsules for combined ultrasound imaging and high intensity focused ultrasound（HIFU） therapy.In this approach,PLGA nanocapsules are prepared firstly and then modified with PDA through the self-polymerization of dopamine.Subsequently,chloroauric acid（HAuCl₄） solution is added,and AuCU" ions are absorbed on the surfaces of the PDA/PLGA nanocapsules and reduced to AuNPs to form AuNPs@PDA/PLGA hybrid capsules.The in vitro experiments show that AuNPs@PDA/PLGA hybrid capsules can provide capability of ultrasound contrast imaging,and the ultrasound-guided HIFU therapy ex vivo with AuNPs@PDA/PLGA hybrid capsules is highly efficient on degassed bovine livers due to the high thermal energy accumulation of AuNPs.更多还原