【作者】 李永芳； 吴雪彬； 李静； 刘岚；

【Author】 Li Yong-fang;Wu Xue-bin;Li Jing;Liu Feng;

【机构】 中山大学海洋学院； 中山大学化学与化学工程学院；

【摘要】 目的对采自福建海百合共附生真菌Aspergillus ruber 1017次级代谢产物进行研究。方法采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、高效液相(HPLC)以及重结晶等方法分离纯化,并根据化合物的理化性质及光谱数据鉴定化合物的结构。结果从海百合共附生真菌Aspergillus ruber1017次级代谢产物中分离鉴定了6个吲哚类生物碱,分别为NeoechinulinA(1),cryptoechinuline G(2),Neoechinulin B(3),Variecolorin H(4),preechinulin(5),cyclo(Trp-Ana)(6)。结论化合物6为首次从海洋真菌中得到。更多还原

【Abstract】 Objective Research on the secondary metabolities of the crinoids epipsymbiosis fungus Aspergillus ruber 1017.Methods The metabolites of Aspergillus ruber 1017 were isolated by silica gel column chromatography,Sephadex LH-20 gel column chromatography,HPLC and recrystal,the structures of compounds were eventually identified and confirmerd on basis of physicochemical,spectral data and compared with the published spectral information.Results Six diketopiperazine indole alkaloids were isolated from Crinoid Epipsymbiosis Fungus Aspergillus ruber 1017,and their structures were identified as Neoechinulin A(1),cryptoechinuline G(2),Neoechinulin B(3),Variecolorin H(4),preechinulin(5),cyclo(Trp-Ana)(6).Conclusion Compound 7 were isolated from marine fungi for the first time.更多还原