【作者】 曾永涛； 段敏；

【Author】 ZengYongtao;Duan Min;Luzhou Mental Health Center;

【机构】 四川省泸州市精神卫生中心；

【摘要】 目的探讨文拉法辛与舍曲林治疗首发抑郁症的临床疗效及安全性。方法选取首发抑郁症患者64例,随机分为2组,分别予以文拉法辛、舍曲林治疗。在治疗前、治疗1周、2周、4周、6周、8周、26周末评定临床疗效及安全性;采用汉密尔顿抑郁量表(HAMD-17)评定临床疗效,副反应量表(TESS)评定药物不良反应。结果 (1)两组治疗前后HAMD总分比较:在治疗26周末,文拉发辛组和舍曲林组的HAMD总分较治疗前都有明显下降,差异都有统计学意义(t=39.296,P<0.001;t=37.547,P<0.001)。(2)两组间抗抑郁显效时间比较:在治疗2周、4周末HAMD总分两组间比较,文拉法辛组比舍曲林组下降明显,差异都有统计学意义(t=–3.269,P<0.01;t=–2.847,P<0.01)。治疗1周末显效率文拉法辛组21.88%>舍曲林组0.00%,治疗2周末显效率文拉法辛组87.50%>舍曲林组53.13%,差异均有统计学意义(P<0.05,P<0.01)。两组临床总疗效比较:26周末两组间总有效率比较和两组间总显效率比较,差异均无统计学意义(x~2=0.129,P>0.05;x~2=0.080,P>0.05)。(3)不良反应比较:文拉法辛组以头昏、血压升高、便秘和食欲减退等4种不良反应多见,舍曲林组以口干口苦、便秘、恶心呕吐等3种不良反应多见。结论文拉法辛与舍曲林的抗抑郁作用在治疗2周后均显效,两种抗抑郁药物的临床疗效肯定,总体临床疗效相当;安全性好,不良反应少;文拉法辛抗抑郁作用起效时间早于舍曲林,在治疗前4周文拉法辛抗抑郁作用的临床疗效优于舍曲林,更能较快控制患者抑郁症状。更多还原

【Abstract】 Objective To discuss venlafaxine and sertraline of first-episode depression treatment efficacy and safety. Methods A case-control study, 64 cases of first-episode depression were randomly divided into two groups,they were to be venlafaxine, sertraline. In order to assess the clinical efficacy and safety of venlafaxine group and sertraline group, The Hamilton depression scale(HAMD-17) was assessed to the clinical curative effect and the effect scale(TESS) was evaluated to the adverse drug reactions to assess the clinical efficacy and safety before treatment, one week, two weeks, four weeks, six weeks, eight weeks, 26 weekend. Results(1)Compare two groups of HAMD total scores before and after the treatment:After treatment 26 weekend, HAMD total scores decreased significantly thanbefore treatment in the venlafaxine group and sertraline group, the differences were all statistical significance(t=39.296,P < 0.001; t=39.296,P < 0.001).(2) Anti-depressant time comparison:HAMD total scores after treatment 2 weekend and 4 weekend compared between the two groups, venlafaxine group decreased significantly than sertraline group,the difference were all statistical significance(t=–3.269,P<0.01; t=–2.847,P<0.01).the clinical effeciency after treatment 1 weekend in venlafaxine group(21.88%)was greater than in sertraline group(0.00%),the efficiency of treatment 2 weekend in venlafaxine group(87.50%) was greater than in sertraline group(53.13%),the differences were all statistical significance(P<0.05, P<0.01).Total clinical curative effect comparison in two groups after the treatment 26 weekend;the total effective rate was and the always show efficiency was(x2=0.129,P>0.05; x2=0.080,P>0.05),the differences were all not statistical significance.(3)Adverse reactions comparison:dizziness,high blood pressure,constipation and loss of appetite were common four kinds of adverse reactions in venlafaxine group;dry mouth pain,constipation,nausea,vomiting were common three kinds of adverse reactions in sertraline group. Conclusion Venlafaxine and sertraline antidepressant effects in the treatment of 2 weeks after takes effect, the clinical curative effect of two kinds of antidepressants, the overall clinical efficacy of fairly; Good safety, less adverse reaction; Venlafaxine antidepressant effects work time is earlier than sertraline, In the treatment of 4 weeks before venlafaxine antidepressant effect of clinical curative effect is better than that of sertraline, more can quickly control in patients with depression symptoms.更多还原