【作者】 蔡晨亮； 屠娟； 郭霞生； 章东；

【Author】 CAI Chen-liang;TU Juan;GUO Xia-sheng;ZHANG Dong;Key Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University;

【机构】 近代声学教育部重点实验室南京大学声学研究所；

【摘要】 研究显示超声造影剂的声孔效应等生物学效应得益于微气泡在超声激励场中的空化效应。本文采用边界元建模的方法来研究在微气泡的瞬态空化中气泡与细胞的相互作用。通过建立三维边界元模型,对有细胞存在的条件下的微泡瞬态空化动力学行为进行了模拟,发现微气泡和细胞的形态在两者相互作用过程中都发生了非球对称的形变,并且在微气泡破裂前后阶段在两者径向方向上产生了射流。本文提出了三个重要参考量来表征细胞的形变程度,并改变了此过程中的几何参数,对微气泡与细胞的相互作用中三个重要参考量的变化进行了更为系统的研究,得到了医学和生物学中可以参考的结论。更多还原

【Abstract】 Previous studies have shown that most therapeutic applications of ultrasound contrast agents(e.g., sonoporation effect) are benefited from the cavitation activities of the microbubbles excited by the ultrasound. The Boundary Element Method(BEM) was adopted to study the interaction between the bubble and the cell in the inertial cavitation. The 3-D BEM simulation results show that asymmetric deformation can be observed for both the bubble and the cell, and an asymmetric collapse is also noticed to happen to the bubble due to the violent cavitation activity. To investigate the influence of microbubble cavitation on the cell, three impact parameters are proposed to examine the membrane deformation of the cell. The geometry parameters were changed to study the interaction between the bubble and the cell under different conditions, so it finally came to some conclusions which can be reference in clinic.更多还原