【作者】 郑燕飞； 王济； 陈雪梅； 佟旭； 孙冉冉； 许璇璇； 胡妮娟； 王琦；

【Author】 ZHENG Yan-fei;WANG Ji;CHEN Xue-mei;TONG Xu;SUN Ran-ran;XU Xuan-xuan;HU Ni-juan;WANG Qi;Beijing University of Chinese Medicine;

【机构】 北京中医药大学；

【摘要】 变应性鼻炎(AR),顽固难愈、复发率高,严重影响患者的生活质量。中医体质学认为AR等过敏性疾病与自身体质密切相关,过敏体质人群机体免疫调适能力低下、对外界致敏原反应增强是导致AR的根本原因。全国名老中医药专家王琦教授从调体入手自拟脱敏止嚏汤,临床观察可有效防治AR。现代免疫学理念认为Th亚群极化后的细胞因子类型决定了机体免疫系统对致敏原的应答状态,鼻腔黏膜Th2极化趋向是AR发生的关键环节,也是干预的重要切入点。前期研究亦发现过敏体质人Th亚群细胞因子调节紊乱。由此提出:Th亚群极化异常是过敏体质的主要分子机制,也是脱敏止嚏汤调体治疗AR的主要作用机制,通过调节Th1/Th2平衡可以从根本上阻断AR的发生发展。更多还原

【Abstract】 Allergicrhinitis(AR) is a stubborn disease of high recurrence rates which seriously affects the quality of patients’ life.TCM Constitution Theory considers that AR and other allergic diseases are both closely related to patients’ own constitution,those of allergic constitutions tend to have lower abilities of body’s immune adjustment and stronger reaction to the outside sensitinogen which are primary causes of AR.ProfessorWangQi-old doctor of TCM,created TuominZhiti decoction from the angle of adjusting constitution,which can effectively prevent and cure AR through clinical observation.Modem immunology believe that the type of cytokine after polarization of Th subgroup determines the response state of body’s immune system to sensitinogen.the polarization trend of Th2 cells of mucosa of nasal cavity is the key point of AR’s happening,also an important pointcut of intervention.Primary study also found that people of allergic constitution usually went through accommodative disorder of Th subgroup cells.The polarization anomaly of Th subgroup cells are the main molecular mechanism of allergic constitution.also the main mechanism of TuominZhiti decoction for regulating constitution to treatment of AR.The occurrence and development of AR can be blocked through adjusting the balance of Th1/Th2.更多还原