【作者】 李琼； 刘海萍； 瞿燕；

【Author】 LI Qiong;LIU Haiping;QU Yan;Ethnic Medicine Institute of Southwest University for Nationalities;College of Pharmacy,Chengdu University of Traditional Chinese Medicine;

【机构】 西南民族大学民族医药研究院； 成都中医药大学药学院；

【摘要】 将盐酸依匹斯汀、预胶化淀粉和微晶纤维素混匀后装填胶囊。考察了原料辅料相容性、胶囊内容物的粉体学性质和溶出度等。初步稳定性考察结果表明,所得盐酸依匹斯汀胶囊在(40±2)℃、相对湿度(75±5)%环境条件下放置6个月或常温放置12个月,含量和溶出度无明显改变,有关物质略有增加。更多还原

【Abstract】 The epinastine hydrochloride,pregelatinized starch and microcrystalline cellulose were mixed and then filled into capsules.The drug-excipient compatibility,powder properties of the mixture of drug-excipient with different weight ratio and in vitro dissolution of the product were investigated.The results of preliminary stability test showed that after storage at(40±2)℃ and relative humidity of(75±5)%for 6 months or at room temperature for 12 months,the content and dissolution did not have significant changes but the amount of related substances had a slight increase.更多还原