消积饮不同治则方药对非小细胞肺癌VEGF表达调控的影响

【作者】 李柳宁； 吴霞； 柴小姝； 张力文； 刘柏； 陈志坚； 何春霞； 洪宏喜；

【机构】 广州中医药大学第二附属医院； 广州中医药大学；

【摘要】 目的:探讨中药复方消积饮的不同治则方药间对非小细胞肺癌VEGF表达调控的影响,揭示其对肿瘤血管生成的可能机制之一。方法:将75例非小细胞肺癌患者,非随机分为A组:健脾补肾+化瘀解毒组;B组:健脾补肾组;C组:化瘀解毒组。每组各25例,三组分别给予相应中药汤剂治疗3个月。治疗前后采用酶联免疫法检测外周血清VEGF的水平,治疗的整个过程对患者进行药物安全性评价。结果:治疗后三组患者血清VEGF值均有不同程度的下降,其中C组血清VEGF值下降的幅度较A组及B组均要显著,差异具有统计学意义(P<0.05);A组的下降幅度较B组的大,差异亦有统计学意义(P<0.05)。结论:消积饮在抗非小细胞肺癌肿瘤血管生成方面,以化瘀解毒法起主要作用,其对抗肺癌侵袭转移的机制有可能是通过抑制血清VEGF水平的表达从而抑制肿瘤血管生成来实现的。更多还原

【Abstract】 Objective:To studythe compound Chinese medicine Xiaoji decoctionamong different therapeutic agent for the elimination of the influence of non-small cell lung cancer tumor angiogenesis,and reveal its one of the possible mechanism of tumor angiogenesis.Methods:75patients with non-small cell lung cancer,non randomly divided into group A:strengthening the spleen and invigorate the kidney + blood detoxification;group B:strengthening the spleen and invigorate the kidney;group C:blood detoxification,each group of 25 cases,three groups were given corresponding Chinese medicine treatment for 3 months.Before and after treatment by enzyme linked immunosorbent assay for VEGF detection in peripheral serum level,Using ELISA detection to detect the patient’s VEGF level,the whole process of the treatment with drug safety evaluationto patients.Results:After treatment,three groups of patients serum VEGF value all have varying degrees of decline,in which the decrease of serum VEGF group C values range from group A and group B were significantly differences statistically significant(P < 0.05);Group A decreased compared with group B,the difference had statistical significance(P<0.05).Conclusion:Xiaoji Decoction on non-small cell lung cancer tumor angiogenesis,with the blood detoxification method,plays a main role,one of its mechanism against invasion and metastasis of lung cancer,may be through inhibiting the expression of serum VEGF level thus inhibiting tumor angiogenesis.更多还原