【作者】 张蔚； 张东友； 刘海峰； 阳义； 韩瑞； 蒋玮丽； 刘兴华；

【Author】 Wei Zhang;Dongyou Zhang;Haifeng Liu;Yi Yang;Rui Han;Weili Jiang;Xinhua Liu;Department of Radiology,Wuhan Chinese and Western Medecine Hospital,Tongji College,Huazhong University of science and technology;

【机构】 武汉市中西医结合医院放射科；

【摘要】 目的:探讨帕金森病(PD)患者针刺治疗前后黑质致密带相位偏移值的变化。材料与方法:收集原发性PD患者42例及健康志愿者30例,其中PD患者Ⅰ~Ⅱ级12例,Ⅲ级~Ⅳ级组30例,针刺治疗3个疗程。应用1.5TMR系统进行头部检查,采用磁敏感成像获得针刺前后黑质致密带相位图,并与正常对照组(30名)进行比较。结果:与正常对照组比较,PDⅠ~Ⅱ级组及Ⅲ级~Ⅳ级组黑质致密带的相位偏移值明显减低(均P<0.05)。针刺治疗前后Ⅰ~Ⅱ级组SNc相位值无明显统计学意义(P>0.05),而Ⅲ级组和Ⅳ级组SNc相位值治疗后较治疗前明显降低(P<0.01)。结论:磁敏感成像技术在评估针刺治疗帕金森病疗效上具有可靠的临床应用价值。更多还原

【Abstract】 Objective To explore the value of 1.5T MR susceptibility weighted imaging(SWI) in acupuncture treatment for Parkinson’s disease changes of pars compacta of substantia nigra(SNc) phase radians.Methods The skull MR scane were applied in 42 cases of patients with Parkinson’s disease and 30 normal controls by 1.5TMR.42 PD patients according to the improvement in Hoehn-Yahr stage PD were divided into grade Ⅰ-Ⅱ12 cases,grade Ⅲ-Ⅳ30 cases,acupuncturing treatment three courses.The susceptibility weighted imaging(SWI) sequence was used to collect phase data.Analyze the data of SNc phase radians before and after treatment in SWI axial images comparing to 30 cases of normal controls.Results Compared with normal control group,SNc phase radians of grade Ⅰ-Ⅱ group before and after acupuncturing treatment was not statistically significant(P>0.05),gradeⅢ-Ⅳ group SNc phase radians after treatment than before treatment was statistically significant(P<0.01).Conclusion:There is a reliable applying SWI to assess clinical value acupuncture treatment in PD patient.更多还原