【作者】 黄丽； 李莉； 兰超； 段国宇；

【Author】 HUANG Li;LI Li;LAN Chao;DUAN Guo-yu;Department of Emergency,The First Affiliated Hospital of Zhengzhou University;

【机构】 郑州大学第一附属医院急救中心；

【摘要】 目的:研究阿托伐他汀对百草枯中毒大鼠肺损伤的保护作用及机制。方法:将50只SD大鼠随机分为对照组、染毒组、阿托伐他汀治疗低、中、高剂量组。染毒组和治疗组百草枯80mg/kg灌胃1次;治疗低、中、高剂量组分别给与阿托伐他汀20mg/kg、40mg/kg、80mg/kg灌胃7天。解剖动物,取肺组织行苏木精-伊红(HE)染色,并检测SOD、GSH-PX水平变化。结果:HE染色结果:染毒组肺损伤较其它各组明显严重,治疗组肺损伤减轻。SOD、GSH-PX测定结果:染毒组与对照组相比明显降低(P<0.05),各治疗组与染毒组相比均有明显升高(P<0.05),各治疗组间有显著性差异(P<0.05)。结论:阿托伐他汀对鼠急性百草枯中毒肺有保护作用,可增加SOD、GSH-PX的活性,存在量效关系。更多还原

【Abstract】 Objective:To Study the effects of atorvastatin in protect the lung injury induced by acute paraquat poisoning in rats.Methods:Fifty SD rats were divided into five groupsxontrol,paraquat poisoning model,treat with low dosage,medium dosage and high dosage atorvastatin group.Paraquat poisoning model group and the treatment groups were given paraquat 80 mg-kg-1 gavage for one time;The treatment groups were respectively given atorvastatin 20mg·kg-1·d-1,40mg·kg-1·d-1,80·kg-1·d-1 gavage for 7 days.The animals were anesthetized and got the lung tissue,then observed the pathological changes by HE staining,and study the changes of SOD and GSH-PX.Results:The result of HE Staining:The lung injury of paraquat poisoning lung is obviously serious than other groups.Treatment groups reduce the lung injury.SOD,GSH-PX determination results:The level of SOD,GSH-PX were significantly lower in poisoning group than those in control group(P<0.05).After seven days treatment,a significant increasing occurred in SOD,GSH-PX level with a dose- dependent manner(P<0.05).Conclusions:Atorvastatin significantly attenuated lung injury induced by acute paraquat poisoning.Its mechanism might be related to the activity increase of SOD、 GSH-PX,and dose-dependent manner.更多还原