【作者】 王丹； 郑建全； 郑向军； 金林培；

【Author】 Dan Wang;Jian-Quan Zheng;Xiang-Jun Zheng;Lin-Pei Jin;College of Chemistry,Beijing Normal University;Beijing Key Laboratory for Bioactive Substances and Functional Foods,Beijing Union University;

【机构】 北京师范大学化学学院； 北京联合大学应用文理学院；

【摘要】 H₂L（结构如下图所示）是一种基于喹唑啉衍生物的荧光传感器,在DMSO/H₂O（1:1,v/v）体系中,它对Cu²⁺具有on-off荧光响应。与铜离子的结合常数可达9.56×10³ M^-2,检出限为4.1×10^-6M。该喹唑啉化合物的铜配合物的结构表明,当H₂L对铜离子响应时,形成了铜席夫碱配合物。基于铜离子和氰根的高亲和力^[1-3],该铜配合物可被用作检测CN^-的turn-on型荧光传感器。在水介质中,其对氰根的检出限可达4.0×10^-6M。细胞成像实验表明H₂L和铜配合物可分别用于检测细胞中的Cu²⁺和CN^-。更多还原

【Abstract】 A fluorescent chemosensor for Cu²⁺ ion based on a quinazoline derivative.,H₂L was designed and synthesized.The binding constant for Cu²⁺ and H₂L is 9.56×10³ M^-2 in DMSO/H₂O（1:1,v/v）,and the detection limit for Cu（Ⅱ）was 4.1×10^-6 M.The crystal structures of the Cu complex,[Cu（HL¹）（Ac）]（1） reveals that the Schiff base complex 1formed in the response system of H₂L to Cu²⁺.Based on the high affinity of Cu²⁺ to CN^-,^[1-3] a complex-based fluorescence turn-on chemosensor for direct detection of CN^-was designed and prepared.It showed high selectivity to CN^-over a number of anions in the aqueous media.The detection limit of CN^-was 4.0×10^-6M.The cell images showed that H₂L and 1 could be used to detect intracellular Cu²⁺ and CN^-,respectively.更多还原