Pd-Catalyzed Asymmetric Decarboxylative Cycloaddtion of Vinylethylene Carbonates with Unsaturated Electrophiles

【作者】 张勇健；

【机构】 上海交通大学化学化工学院；

【摘要】 The development of efficient methods for the construction of quaternary stereogenic centers is an important objective in asymmetric catalysis.In this presentation,I will present our recent research results for the construction of quaternary stereogenic centers via palladium-catalyzed asymmetric decarboxylative cycloaddition of vinylethylene carbonates（VECs）with unsaturated electrophiles.By using chiral palladium complex as catalysts under mild conditions,the transformations afford tertiary vinylglycols,^[1]α-tertiary amino alcohol derivatives^[2]and highly functionalized tetrahydrofurans bearing contiguous tertiary and vicinal all-carbon quaternary stereocenters^[3]in high yields and high levels of stereoselectivities（Fig.1）.更多还原

【Abstract】 The development of efficient methods for the construction of quaternary stereogenic centers is an important objective in asymmetric catalysis.In this presentation,I will present our recent research results for the construction of quaternary stereogenic centers via palladium-catalyzed asymmetric decarboxylative cycloaddition of vinylethylene carbonates（VECs） with unsaturated electrophiles.By using chiral palladium complex as catalysts under mild conditions,the transformations afford tertiary vinylglycoIs,^[1] a-tertiary amino alcohol derivatives^[2] and highly functionalized tetrahydrofurans bearing contiguous tertiary and vicinal all-carbon quaternary stereocenters^[3] in high yields and high levels of stereoselectivities（Fig.1）.更多还原