【作者】 邹雪； 赵晓文； 叶林；

【Author】 ZOU Xue;ZHAO Xiaowen;YE Lin;State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute of Sichuan University;

【机构】 四川大学高分子研究所,高分子材料工程国家重点实验室；

【摘要】 <正>有利于提高生物利用度及降低毒副作用的响应性药物释放体系已成为当今给药技术的发展趋势,而在多种响应性释放系统中,随着全世界糖尿病人口的逐年增加,葡萄糖响应性输送系统越来越受到关注。葡萄糖响应性控释体系通常通过葡萄糖氧化酶对葡萄糖的催化反应赋予pH敏感性凝胶葡糖响应性^[1]。壳聚糖（Chitosan）作为一种天然可降解高分子聚合多糖,具有一定的pH响应性能,但当其作为葡萄糖响应性药物控释体系载体时,存在溶胀转变pH更多还原

【Abstract】 In general,glucose-sensitive controlled delivery systems can be prepared with pH sensitive gels and glucose oxidase(GOD),since GOD can react with glucose to form gluconic acid which triggers the pH-sensitive swelling/deswelling of the gels in different glucose concentration.Chitosan is a kind of natural biodegradable polycationic polysaccharide,however,its poor pH responsibility limited the application in glucose sensitive drug release systems.In this study,to solve this problem,chitosan was chemically modified using cationic quaternary ammonium monomer(CQAM) and quatemized chitosan(HTCC) microgels were prepared.The results showed that CQAM was confirmed to be grafted onto the molecular chain of chitosan successfully by ~1H NMR analysis.With increasing degree of substitution,storage modulus(G’) and crosslinking density(X_c)of HTCC microgels decreased,but mesh size(L_c) increased.The drug release behavior of HTCC microgels with DS 197%exhibited obvious pH and glucose responsive release behavior.更多还原