Synthesis of Furocoumarins via Cascade Palladium Catalyzed Oxidative Alkoxylation of 4-Oxohydrocoumarins and Styrenes

【作者】 Xian-Chun Tan； Hai-Yuan Zhao； 吴娜； 潘英明；

【Author】 Xian-Chun Tan;Hai-Yuan Zhao;Na Wu;Ying-Ming Pan;

【机构】 广西师范大学化学与药学学院；

【摘要】 <正>Coumarins are important structural units in several natural products,and feature widely in biologically active compounds.Furocoumarins are potent anti-breast cancer agents,which exhibithigh tumor tissue-type as well as breast cancer cell line selectivity(Figure 1),like Neo-tanshinlactone and Coumestrol.For this reason,considerable efforts have been expended to develop furocoumarins.Sameh R and Risitano groups applied respectively a tandem Oalkylation/cyclisation of 4-hydroxycoumarin and haloketones to synthesize furo[3,2-c]coumarin derivatives;更多还原