Enantioselective Synthesis of Chiral 1,2-Amino Alcohols Via Asymmetric Hydrogenation of α-Amino Ketones with Chiral Spiro Iridium Catalysts

【作者】 Ke Wang； Ming-Lei Yuan； 谢建华； 周其林；

【Author】 Ke Wang;Ming-Lei Yuan;Jian-Hua Xie;Qi-Lin Zhou;State Key Laboratory and Institute of Elemento-organic Chemistry,Nankai University;

【机构】 State Key Laboratory and Institute of Elemento-organic Chemistry,Nankai University；

【摘要】 <正>Catalytic asymmetric hydrogenation of ketones with chiral transition metal catalysts is one of the most powerful methods for the preparation of chiral alcohols.Chiral 1,2-amino alcohols are very common structural motifs in a wide range of bioactive natural products,and the asymmetric hydrogenation ofα-amino ketoneswith chiral rhodium and ruthenium complexes bearing chiral diphosphine ligands has developed into an efficient method for the enantioselective synthesis of chiral 1,2-amino alcoholsduring the past decades.However,highly efficient chiral catalysts for更多还原