Synthesis of Ferrocene Derivatives with Planar Chirality via Palladium-catalyzed Enantioselective C-H Bond Activation

【作者】 皮超； 刘秀艳； 崔秀灵； 吴养洁；

【Author】 Chao Pi;Xiuyan Liu;Xiuling Cui;Yangjie Wu;

【机构】 郑州大学化学与分子工程学院；

【摘要】 <正>Ferrocene bearing planar chirality is a powerful chiral ligand in asymmetric reaction.~1 However,highly enantioselective synthesis of such compounds has been a longstanding challenge.Traditional methodologies are less tolerant of functional groups in the substrates,and suffer from harsh reaction conditions,low atom economy and requirement of the excessive amount of lithium reagents.Although 2-acyl-1-dimethylaminomethylferrocene with planar chirality is an important structural更多还原