Rh~I-Catalyzed Enantioselective Hydrogenation of Substituted Acrylic Acids with Sterically Similar β,β-Diaryls

【作者】 李洋； 董开武； 王正； 丁奎岭；

【Author】 Yang Li;Kaiwu Dong;Zheng Wang;Kuiling Ding;State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences;

【机构】 State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences；

【摘要】 <正>Optically activeβ,β-diarylpropionic acids represent a class of important building blocks for asymmetric synthesis of chiral diarylmethine compounds,which are the structural moieties occurring in many pharmaceuticals and bioactive compounds.¹ Although several methods for the preparation ofβ,β-diarylacrylates have been reported,asymmetric hydrogenation ofβ,β-diarylacrylates with molecular H₂ is more advantageous.In this respect,Ir¹-or Rh¹-catalyzed asymmetric hydrogenation of trisubstituted olefins for the formation of diarylmethine stereogenic centers seems feasible.² However,reactions involving 3,3-diarylacrylates（especially free acids）更多还原