NHC-Au(I)-catalyzed synthesis of benzo[b][1,4]diazepines from N-substituted o-phenylenediamines and terminal alkynes

【作者】 Pei Guo； Xiaoming Zeng； Si Chen； 罗美明；

【Author】 Pei Guo;Xiaoming Zeng;Si Chen;Meiming Luo;College of Chemistry,Sichuan University;Frontier Institute of Science and Technology,Xi′ an Jiaotong University;

【机构】 College of Chemistry,Sichuan University； Frontier Institute of Science and Technology,Xi′ an Jiaotong University；

【摘要】 <正>Benzo[b][1,4]diazepine nucleus is an important nitrogen-containing pharmacophoric motif.Many benzo[b][1,4]diazepine derivatives exhibit biological and pharmacological activities,such as sedative,hypnotic,antihistaminic,anticonvulsant,antianxiety,antidepressive,anti-inflammatory activities.1 Traditional methods for the preparation of benzo[b][1,4]diazepines include the condensation of o-phenylenediamine with ketones,更多还原