【作者】 李绘； 周书娟； 孙德志；

【Author】 Li Hui;Zhou Shujuan;Sun Dezhi;College of Chemistry and Chemical Engineering, Liaocheng University;

【机构】 聊城大学化学化工学院；

【摘要】 应用循环伏安法测定了常温下β–环糊精(结构见图1)[1]分别与三种具有抗肿瘤活性的香豆素衍生物7–羟基香豆素、4–羟基香豆素及6–甲基香豆素(分子结构见图2)共存于氯化钾水溶液中时铂碳电极上的峰电流。据这些实测的电化学数据求算了三种主—客体包合物的标准稳定常数Kθ(表1)[2]。所得热力学参数表明,三种药物与该环糊精包合物的稳定性依次减弱。这样的结果说明,刚性客体分子骨架上取代基的位置和种类对主—客体分子识别有着重要影响。更多还原

【Abstract】 Peak current(i) through platinized carbon electrode has been determined when β–cyclodextrin[1](see molecular structure in Figure 1) is in coexistence of each of the three derivatives of coumarin possessing antitumor activity, 7-hydroxylcoumarin, 4-hydroxylcoumarin, and 6-methylcoumarin(see molecular structures in Figure 1 a- c), in aqueous KCl solutions. The standard stability constants of the three host – guest inclusion complexes have been calculated based on the determined electrochemical data and put in Table 1[2]. These thermodynamic parameters indicate that the stability of the CD complex with the above mentioned three drugs becomes weak one by one. This result means that position and type of substituent on rigid guest molecule can evidently influence host – guest molecular recognition.更多还原