【作者】 游乐星； 郭俊玮； 孙建军；

【Author】 Le-Xing You;Jun-Wei Guo;Jian-Jun Sun;Key Laboratory of Analysis and Detection Technology for Food Safety, Ministry of Education, College of Chemistry and Chemical Engineering, Fuzhou University;

【机构】 福州大学食品安全分析与检测技术教育部重点实验室；

【摘要】 <正>莽草酸作为一种重要的药物中间体,能在生物体内合成并代谢形成多种化合物,如具有抗炎和抗菌效果的芳香族化合物。经过多步骤的衍生化反应和纯化,莽草酸能形成更有效的抗病毒药物,如达菲——一种著名的治疗禽流感的药物。目前,我们发现铜电极经过氧化后具有很强的催化能力并能电更多还原

【Abstract】 Shikimic acid, a key pharmacological intermediate, has anti-bacterial and anti-tumor effects in its metabolism. Through multi-step derivative reaction and purification, it can form into more effective antiviral drug such as ‘Tamiflu’. In situ FTIRS can be used to monitor and identify the solution products in molecular level. As the potential is applied between 0.1 V and 0.2 V vs. SCE, SA is oxidized to 3-dehydroshikimic acid(DHS). Then a significant change appeared when the potential is from 0.3 V to 0.8 V, DHS is decomposed to transaconitate and formate. As the potential is over 0.9 V, formate is further oxidized to CO2.更多还原