STAT3 activation and CCL2 production induced by FAP in fibroblasts is important for immunosuppressive myeloid cell infiltration and tumor growth

【作者】 林玉丽； 史颖弘； 杨旭光； 李冰骥； 邓博； 刘卫仁； 储以微； 樊嘉； 何睿；

【机构】 复旦大学医学院免疫学系；

【摘要】 <正>Fibroblasts,as the most abundant cell type in the tumor stroma,play important roles in cancer development through various mechanisms.In addition to the effect of cancer associated fibroblasts(CAFs)on tumor cell biology and angiogenesis,recent studies have demonstrated that CAFs exhibit a pro-inflammatory gene signature and orchestrate tumorpromoting更多还原