【作者】 兰淑娟； 王新梅； 靳岱红； 魏晶；

【机构】 青岛市第九人民医院呼吸内科；

【摘要】 目的:研究喘可治与硫酸沙丁胺醇气雾剂吸入治疗哮喘的临床疗效。方法:将我院收治的90例支气管哮喘患者纳入研究对象,采用随机数字表法分为观察组和对照组各45例。观察组患者接受喘可治联合糖皮质激素吸入治疗,对照组患者接受硫酸沙丁胺醇气雾剂联合糖皮质激素吸入治疗。比较两组临床症状、肺功能与血气指标、炎症因子与T细胞亚群。结果:①临床症状:观察组咳嗽、喘息、憋闷、喉中痰鸣、肺部哮鸣音等积分均明显低于对照组（0.65±0.05 vs 1.78±0.32,1.02±0.06 vs 1.68±0.35,0.68±0.07 vs 1.65±0.34,1.04±0.03 vs 1.86±0.26）（P<0.05）;②肺功能与血气指标:观察组PEV1、PEF、PaO₂明显高于对照组[（9.32±8.41 vs 74.01±7.85）ml/s,（80.12±8.45 vs 73.46±8.32）,（85.31±9.02 vs 76.58±8.02）mmHg]（P<0.05）,PaCO₂明显低于对照组（33.82±4.14 vs 40.56±4.55）mmHg（P<0.05）;③炎症因子与T细胞亚群:观察组血清TNF-α、IL-6、IL-8含量明显低于对照组（14.24±1.94 vs 23.15±2.96,7.42±0.98 vs 12.27±1.82,9.23±1.15 vs 14.29±2.01）ug/L（P<0.05）,外周血中Th1含量明显高于对照组（22.13±3.42 vs 15.84±2.28）（P<0.05）,Th2细胞含量明显低于对照组（12.28±1.85 vs 17.38±2.32）（P<0.05）。结论:喘可治治疗有助于缓解支气管哮喘的临床症状,改善肺功能及血气指标,抑制炎症反应,调节免疫平衡,提高治疗效果,可作为糖皮质激素的补充治疗。更多还原

【Abstract】 Objective:To study the effect of chuankezhi and Salbutamol Aerosol inhalation in treating Asthma.Methods:90 cases patients with bronchial asthma in our hospital were enrolled and randomly divided into observation group and control group.Observation group received chuankezhi injection combined with glucocorticoid inhalation treatment,control group received Salbutamol Aerosol combined with glucocorticoid inhalation treatment.Then clinical symptoms,pulmonary function and blood gas index,inflammatory factors and T cell subgroup were compared between two groups.Results:①Clinical symptoms:observation group cough,wheezing,oppressed,throat phlegm,lungs wheeze score were significantly lower than the control group（0.65 ±0.05 vs 1.78 ±0.32,1.02 ± 0.06 vs 1.68 ± 0.35,0.68 ± 0.07 vs 1.65 ± 0.34,1.04 ± 0.03 vs 1.86 ± 0.26）（P < 0.05）;② Lung function and blood gas index;observation group PEV1,PEF,PaO₂ wassignificantly higher than that of control group[（9.32 ±8.41 vs 74.01 ±7.85）ml/s,（80.12 ±8.45 vs 73.46 ±8.32）,（85.31 ±9.02 vs76.58 ±8.02）mmHg]（P<0.05）,PaCO₂ was significantly lower than the control group（33.82 ±4.14 vs 40.56 ±4.55） mmHg（P <0.05）;③ Inflammatory factor and T lymphocyte subsets:Observation group serum TNF alpha,IL- 6,IL- 8 content were significantly lower than that control group（14.24 ±1.94 vs 23.15 ±2.96,7.42 ±0.98 vs 12.27 ±1.82,9.23 ±1.15 vs 14.29 ±2.01） ug/L（P<0.05）,peripheral blood Thl content was significantly higher than that control group（22.13 ±3.42 vs 15.84 ±2.28）（P<0.05）,Th2 cells waw significantly lower than that control group（12.28 ±1.85 vs 17.38 ±2.32）（P<0.05）.Conclusion:Chuankezhi treatmen helps to relieve the clinical symptoms,improve lung function and blood gas index,inhibit inflammation,regulating immune balance,improve the effect of treatment,can be used to supplement treatment of glucocorticoid.更多还原