【作者】 王朋； 崔邦平； 代文莉； 胡涛； 严凯； 胡伟； 蒋长斌；

【Author】 WANG Peng;CUI Bang-ping;DAI Wen-li;HU Tao;YAN Kai;HU Wei;JIANG Chang-bin;The First College of Clinical Medical Science,China Three Gorges University Department of Nuclear Medicine of Yichang Central People’s Hospital Key Laboratory of Molecular Imaging of Yichang;

【机构】 三峡大学第一临床医学院； 宜昌市中心人民医院核医学科； 宜昌市分子影像重点实验室；

【摘要】 目的探讨上尿路梗阻肾积水患者肾动态显像时感兴趣区（ROI）应如何选择。方法采用^99mTc-DTPA肾动态显像,对45例患者分别以全肾及肾皮质作为ROI,用Gates法计算GFR值,并与同期检测的24 h尿微量白蛋白（24hUmAlb）、24 h尿蛋白定量（24 hPro）结果进行相关性分析。所有患者均有较好的检查前准备及较高的核素弹丸注射质量。结果随积水程度加重,由2种ROI计算的GFR均下降,同期24 hUmAlb、24 hPro均升高。整体上看,与全肾ROI相比,采用肾皮质ROI计算的GFR值与24 hUmAlb、24 hPro有更好的相关性。结论 ^99mTc-DTPA肾动态显像是一种无创伤、灵敏、准确评价肾功能的检查方法。在上尿路梗阻放射性核素滞留的患肾,设定全肾ROI所测的GFR可能低估了梗阻肾功能受损的程度,采用肾皮质ROI是更合理的选择。更多还原

【Abstract】 Objective To discuss how to choose the region of interest（ROI） at renal dynamic imaging in upper urinary obstruction patients.Methods Using ^99mTc-DTPA renal dynamic imaging,Gates method respectively in the whole kidney and renal cortex of ROI calculated the renal GFR of45 cases,and we detected the 24 hours urine albumin（24 hUmAlb） and Urine protein quantitative（24 hPro） for correlation analysis.All patients have better check preparation and higher quality of nuclide projectile injection.Results With the aggravation of water,GFR decreased which calculated by two ROI means,24 hUmAlb and 24 hPro all rise at the same time.Overall,compared with the renal ROI,the GFR values calculated by renal cortex ROI have better correlation to 24 hUmAlb and 24 hPro.Conclusions When the upper urinary tract obstruction patients who at renal dynamic imaging with radionuclide retention,setting total renal ROI to calculate the GFR maybe underestimate the degree of impaired renal function,and using renal cortex ROI is a more reasonable choice.更多还原