【作者】 王锦霞；

【Author】 Wang Jinxia Beijing Hui Long Guan Hospital,Beijing 100096

【机构】 北京回龙观医院；

【摘要】 目的:探讨精神分裂症认知功能损害与阴性、阳性症状的关系。方法:对73例入组的患者随机给予利培酮、氯氮平治疗12周,并于治疗前、后盲法评定①WISCONSIN 卡片分类测验(WCST);②WECHSLER 记忆测验(WMS);③阴性症状量表(SANS);④阳性症状量表 (SAPS)。结果:治疗前精神分裂症患者的阴性症状、阳性症状均与认知功能有显著相关。主要与执行功能相关;注意障碍与记忆相关。治疗后,仅 SAPS 中怪异行为得分与 WCST 的持续反应数、持续错误数显著相关。结论:精神分裂症的认知功能损害是原发性的,并不是在阳性、阴性症状基础上产生的。更多还原

【Abstract】 Objective:To explore the relationship between cognitive function impairment and negative symptoms and positive symptoms for Schizophrenic patients.Method:73 Schizo- phrenic patients were treated randomly with risperidone and clozapine for 12 weeks.They were assessed by WCST,SANS,SAPS separately before and after 12 weeks treatment.Results:Both negative symptoms and positive symptoms before treatment were correlated significantly with cog- nitive symptoms.They were correlated mainly executive function;Attention impairment was cor- related with memory.After treatment,only was bizarre behaviour of SAPS correlated with perse- verative respond and perseverative errors of WCST.Conclusion:Cognitive function of Schizophre- nia is primary symptoms,not based on negative symptoms and positive symptoms.更多还原