【作者】 梁勇； 方昆阳； 郭宝江； 梁冠洪； 宋艳平；

【Author】 LIANG Yong, FANG Kun-yang, GUO Bao-jiang, LIANG Guan-hong, SONG Yan-ping (1. Department. of Chemistry, South China Normal University, Guangzhou 510631, China;2. Institute of Life Science, South China Normal University, Guangzhou 510631, China)

【机构】 华南师范大学化学系； 华南师范大学生命科学学院；

【摘要】 <正> 牛膝,又名百倍、怀牛膝、鸡胶骨,为苋科植物牛膝(Achyranthes bientata BI)干燥的根。药理研究表明:它具有保肝降酶、降血脂、强心的作用,能显降低血清中甘油三脂、胆固醇和β脂蛋白的含量。牛膝中含牛膝皂苷,其苷元为齐墩果酸,属五环三萜类化合物,是主要活性成分。电喷雾质谱以其灵敏度高、快速、简便等特点在生物化学领域中有着十分广泛的应用。电喷雾串联质谱(ESI-MS~n)能直接分析溶液样品,由于不存在样品加热汽化的过程,因而特别适合分析强极性、难挥发或热不稳定的化合物。更多还原

【Abstract】 Achyranthosidel and Achyranthoside Ⅱ which were considered to be effective constituents from Achyranthes bientata BI were identified by electrospray tandem ionization massspectrometric(ESI-MS~n)methods after macro-porous adsorbent chromatographic separation. Their characteristic mass spectra can be use as fingerprint for the identification of Achyranthosidel and Achyranthoside Ⅱ. This method is simple., rapid and highly sensitive.更多还原