【作者】 张幸； 杨大里； 娄金萍； 何振怡； 钟惠仙； 张朝和；

【Author】 Zhang Xing,Yang Da-li,Lou Jin-ping,et al (Institute of Hygiene ,Zhejiang Academy of Medical Sciences ,Hangzhou,310013)

【机构】 浙江省医学科学院卫生学研究所； 浙江东风莹石集团公司职工医院；

【摘要】 目的观察低浓度克矽平大容量全肺灌洗术治疗煤工尘肺的疗效。方法 42名男性煤工尘肺患者用分层配对方法确定治疗组和对照组。治疗组21名患者接受大容量肺灌洗术治疗。两组随访时进行问诊调查、肺功能和胸部x线摄片检查。结果肺灌洗治疗能洗出一定量的粉尘,其中快型尘肺平均每例的粉尘洗出量为 981．2mg,明显多于慢型尘肺(386．2mg),差异有显著性(P<0．05);治疗组疗前、疗后2年、疗后6年的FEV1.0值分别为 3．35、3．29和2．75L,对照组为2．95、2．73和2．41L,均随年龄增加有下降趋势,但两组的差异无显著性(P>0．05)。治疗组治疗后6年胸片的稳定率和进展(进展及明显进展)率分别为42．1％和57．9％,对照组分别为57．9％和42．1％,两组的差异无显著性(P>0．05)。结论大容量全肺灌洗术能洗出肺内一定量的粉尘,但对肺功能改善和阻止病变进展未见明显疗效。更多还原

【Abstract】 Objective To observe the curative effect of large volume whole lung lavage with low concentration of poly-2-vinyl pyridine-n-oxide (P204) on the coal workers’ pneumoconiosis. Methods 42 male patients were selected as research subjects.21 patients were selected to accept the treatment and another 21 as controls.A standard questionnaire investigation,lung function and chest X-ray examination were done in both groups of the patients.Results The mean amount of dust washed out from a patient’s lung was 981.2 mg in the rapid-type patient group and 386.2 mg in the slow-type patient group (P<0.05).Before treatment and 2 years,6 years after treatment, the value of FEV1.0,were 3.35 L.3.29 L and 2.75 L respectively in the treatment group,and 2.95 L,2.73 L and 2.41 L respectively in the control group.Lung function decreased in both groups by aging without statistical difference (P>0.05).6 years after treatment,the rate of stability and aggravation of X-ray examination of chest were 42.1% and 57.9% in treatment group and 57.9% and 42.1% in control group,respectively without statistical difference (P>0.05).Conclusion The dust could be washed out from the lung by large volume whole lung lavage but there were no evidences of improvement of lung function and prevention from aggravation of pathological change 6 years after treatment.更多还原