【作者】 闻礼永； 李思温； 吴玲娟； 杨纪顺； 严晓岚； 杨明瑾； 漏磊君； 詹福初； 汪旭阳； 李土荣； 邵坚强； 郑金春； 傅美华；

【Author】 Wen Li-yong, Li Si-wen,Wu Ling-juan,et al (Institute of Parasitic Diseases,Zhejiang Academy of Medical Sciences,Hangzhou, 310013)

【机构】 浙江省医学科学院寄生虫病研究所； 常山县地方病防治站；

【摘要】 目的观察伊维菌素驱治肠道线虫感染的效果及副作用。方法用伊维菌素0．1、0．2、0．2和0．2mg/kg 顿服分别治疗蛔虫、钩虫、鞭虫和蛲虫感染者,并与阳性对照药阿苯达唑400mg顿服进行比较。结果随机双盲治疗,伊维菌素和阿苯达唑对蛔虫感染的虫卵阴转率均为100％(34／34),对钩虫感染的虫卵阴转率分别为 17．6％(6/34)和76．5％(26／34),对鞭虫感染的虫卵阴转率分别为67．6％(23／34)和47．1(16／34),对蛲虫感染的虫卵阴转率分别为58．8％(20／34)和100％(34／34)。服药后1~2d排虫达高峰。不良反应发生率低,血液学、肝肾功能和心电图检查无明显影响。结论伊维菌素治疗鞭虫感疗效优于阿苯达唑,治疗蛔虫感染疗效与阿苯达唑相同,治疗钩虫、蛲虫感染疗效不及阿苯达唑。更多还原

【Abstract】 objective To observe the efficacy and side effects of ivrmectin in the treatment of intestinal nematode infections.Methods A single dose of ivermectin 0.1,0.2,0.2and 0.2mg/kg was orally administered to cases with infection of Ascaris,hookworm,Trichuris and Enterobius respectively A,single dose of albendazole 400mg was used as control.Results The egg negative conversion rates of ivermectin and albendazole were both 100% (34/34) for Ascaris infection, 17.6%(6/34) and 76.5%(26/34)respeceively for hook worm infection,67.6%(23/34) and 47.1%(16/34)respectively for Trichuris infection,58.8%(20/34) and 100%(34/34)respectively for Enterobius infection.The worm discharge reached a peak in 1 ~2 days after treatment.The side effect of ivermectin was mild and transient showing no adverse effect on blood picture, liver function,renal function or ECG. Conclusion Ivermectin shows similar effect on Ascaris with albendazole,better effect on Trichuris and poorer effect on hookworm and Enterobius than albendazole.更多还原