【作者】 徐哲明； 潘大津； 程英； 朱满莲； 叶双樱；

【Author】 PAN DAJIN XU ZHEMING WU SHONGCHANG YE SHUANGYIN ZHU MANLIAN CHENGYIN.LISHUI SECOND PEOPLE’S HOSPITAL,LISHUI 32300,CHINA

【机构】 浙江省丽水市第二人民医院；

【摘要】 目的评价多奈哌齐(安理申)治疗血管性痴呆病(VASCULAR DEMENTIA,VAD)的有效性及安全性。方法将60例 VAD 患者随机均分为多奈哌齐组(30例)和安慰剂组(30例),治疗8周。采用简易精神状态量表(MMSE),临床疗效总评量表(CGI)评定疗效,用副反应量表(TESS) 及有关实验室检查评定副反应。结果两组治疗8周后,多奈哌齐组简易精神状态量表(MMSE)评分明显提高 (P<0.05)。治疗期间两组副反应量表(TESS)评分无显著性差异(P>0.05)。结论多奈哌齐能改善轻、中度 VaD 患者的认知功能和痴呆程度,且耐受性好,安全性高。更多还原

【Abstract】 OBJECTIVE AND TOLERABILITY OF DONEPEZIL IN PATIENTS WITH VASCULAR DEMENTIA (VAD).METHOD THE 70 CASES OF MILD TO MODERATE VASCULAR DEMENTIA WERE RANDOMLY DIVIDED INTO THE DONEPEZIL GROUP(36SUBJECTS) AND THE PLACEBO GROUP(34 SUBJECTS).THE EFFICACY AND ADVERSE SIDE EFFECTS WERE JUDGED BY MMSE,CGI,HAMD,ADL,ZVT,TESS AND LAORATORY INVESTIGATIONS CONCERNED BEFORE ANDDURING THE FOURTH,EIGHTH WEEK OF THE TREATMENT COURSE. RESULTS PATIENTS TREATED WITH DONEPEZIL FOR EIGHT WEEKS SHOWED SIGNIFICANTLY MORE IMPROVEMENT IN THE MMSE AND ADL SCORES AND ZVT TEST OVER THE PLACEBO GROUP.THE INCIDENCE OF ADVERSE SIDE EFFECTS WAS LOW ANDCOMPARABLE TO THE PLACEBO GROUP.CONCLUSION DONEPEZIL IS EFFECTIVE IN THE TREATMENT OF VASCULAR DEMENTIA.IT CAN IMPROVE COGNITION ANDABILITY OF DAILY LIFE,AND IT WAS WELL TOLERATED AND SAFE.更多还原