脱氧吡啶啉在肺癌骨转移诊断中的研究

【作者】 卢丽琴； 袁国荣； 张苏展； 钦志泉； 薛骞； 赵同伟； 高亮； 郑爱红；

【机构】 浙江省人民医院肿瘤科； 浙江大学医学院附属二院；

【摘要】 目的:探讨脱氧吡啶啉对肺癌骨转移诊断的意义;方法:182例肺癌病人分骨转移组和无骨转移组,进行尿脱氧吡啶啉／尿肌酐(uDPD／Cr)、尿钙／尿肌酐 (uCa／Cr)、血清钙(sCa)、血清碱性磷酸酶(sAKP)比较,及其对肺癌骨转移诊断的敏感度、特异度统计及比较;对其中80例肺癌无骨转移病人进行了6个月的追踪观察。结果:肺癌骨转移组uDPD／Cr为12．35±2．65nmol／mmol,肺癌无骨转移组uDPD／Cr 为7．76±2．11nmol／mmol,肺癌骨转移组高于肺癌无骨转移组(p<0．01);uDPD／Cr 诊断肺癌骨转移的敏感度、特异度分为86％和65％;80例肺癌无骨转移病人初测 uDPD／Cr正常组6个月后骨转移率为17．4％,初测uDPD／Cr升高组6个月后骨转移率为55．9%;二组比较有显著性差异(p<0．01);结论:尿脱氧吡啶啉对肺癌骨转移早期诊断和诊断有较大的临床意义。更多还原

【Abstract】 Aim To explore significance of oxypyridinoline to diagnosis on osseous metastasis of lung cancer . Method 182 cases with lung carcinoma was divided into two groups. One group was canse with osseous metastasis, the other group was cases without osseous metastasis. uDPD/Cr, uCa/Cr, sCa and sAKP in two groups were respectively compared . Sensitivity and specificity of these indexes to diagnosis on osseous metastasis of lung cancer were calculated and compared. 80 cases without osseous metastasis had been on follow-up for 6 months. Result uDPD/Cr of group with osseous metastasis and without osseous metastasis was 12. 35±2.65nmol/ mmol and 7. 76 ±2. 11nmol/ mmol respectively. uDPD/Cr of group with osseous metastasis was higher than ratio of group without osseous metastasis and the difference is significant in statistics (p<0. 01) . Sensitivity and specificity of uDPD/Cr to diagnosis on osseous metastasis of lung cancer were 86% and 65%. Ratio of osseous metastasis of cases with normal uDPD/Cr at first was 17. 4%. On contrast, ratio of osseous metastasis of cases with high uDPD/Cr at first was 55.9% and the difference is significant in statistics (p<0.01 ) . Conclusions uDPD has large significance on early diagnosis and diagnosis to diagnosis on osseous metastasis of lung cancer.更多还原