【作者】 王鑫； 刘瑞春； 杨敬芳； 时东彦； 赵宝珍；

【Author】 LIU Ruichun, WANG Xin,YANG Jingfang,SHI Dongyan,et al. Department of Neurological lab, Clinical Microbiological Lab,The 2nd Hospital of HeBei Medical University .Shinjiazhuang ,HeBei,050000

【机构】 河北医科大学第二医院神经内科； 河北医科大学第二医院检验科；

【摘要】 目的研究检测脑脊液中抗新型隐球菌抗体IgG对隐球菌性脑膜炎(CNM)的临床诊断价值。方法采用间接ELISA法检测脑脊液中抗新型隐球菌抗体IgG,检测178例临床病例,包括CNM、脑囊虫、结核性脑膜炎、病毒性脑膜炎、脑瘤、小儿病毒性脑膜炎、小儿化脓性脑膜炎等患者和42例正常人。结果 178例患者中,15例患者抗隐球菌抗体IgG阳性,其中包含5例CNM确诊的患者、26 例结核性脑膜炎患者中有4例、9例脑膜脑炎中2例、38例脑囊虫患者中1例、12例病毒性脑炎中1 例、7例小儿化脓性脑膜炎中1例、7例免疫风湿病中1例。结论间接FLISA法检测抗新型隐球菌抗体IgG对CNM的诊断有较高的灵敏度和特异性,具有重要的临床应用价值。更多还原

【Abstract】 Objective: To investigate the value of diagonosis on ditecting anti-cryptococcus neoformans antibody( IgG ) in patients with CNM. Methods :The anti-cryptococcus neoformans antibody( IgG ) of CSF in 136 patients and 42 healthful persons were determined by indirect-ELISA, which include CNM、 Cerebral Cyspicercosis Meningocerebritis,tuberculous meniingitisViral meningitis,Cerebral tumor、 Infantile suppurative leptomeningitis,Immune rheumatism. Results: 15 cases were positive.which comprises 5 cases with CNM ,4 cases with Tuberculous meniingitis, 1 case with Cerebral Cyspicercosis ,2 cases with Meningocerebritis ,1 case with infantile suppurative leptomeningitis、 1 case with viral meningitis ,1 case with immune rheumatism. Conclusion: The level of anti- cryptococcus neoformans antibody (IgG) in CSF determined by indirect-ELISA could privide the base of diagnosis on CNM.更多还原