【作者】 仲恒高； 聂继华； 苗超； 臧黎慧； 苏世标； 童建；

【机构】 苏州大学放射医学与公共卫生学院卫生毒理教研室；

【摘要】 [目的]研究氡及其子体联合烟草吸入对大鼠肺与血细胞的氧化应激损伤。[方法]雄性Wistar大鼠20只,随机分为4组,除对照组外,1组暴露于多功能生态氡室,吸入氡及其子体的累积剂量达105工作水平月(working level month,WLM),2组置于动式气体染毒装置,以35%的香烟烟雾30分钟、每日一次,连续染毒,3组同时暴露于1、2两种处理因素。检测各组大鼠肺组织匀浆以及外周血的超氧化物歧化酶(SOD)、丙二醛(MDA)含量。[结果]与对照组相比,各处理组SOD含量均有降低(p<0.01),MDA均有上升(p<0.01),1、2组间无显著性差异,3组与各组相比SOD均显著下降,MDA显著上升。[结论]在本实验条件下,氡及其子体、烟草单独吸入以及两者的联合吸入,均可扰乱了大鼠的氧化应激平衡体系,使其受到一定的损伤,而联合吸入的损伤尤重。更多还原

【Abstract】 [Objective] To study the redox damage of lung ang blood in rats inhaled radon and Tabacco smoking. [Methods] 20 Male Wistar rats set to 4 groups randomly.Rats in Group1 were exposed to radon and its progeny with the cumulative dose up to105 working level month(WLM) except control group,Group 2 inhaled 35% Tabacco smoking 30 minutes once everyday,Group 3 treated with both randon and tobacco smoking . The lever of SOD (superoxide dismutase) and MDA (malondialdehyde) in blood and lung tissue were investigated respectively.[Result] The lever of SOD in blood and lung tissues sibnificantly decreased and the lever of MDA increased. The changes of rats in Group 3 are more significant. [Conclusion] The inhallation of radon and tabacco smoking can lead to the persistent disturbance of the redox state in rats,and the combine group are more serious.更多还原