【作者】 叶晓川； 陈华兵； 徐辉碧； 杨祥良；

【Author】 Xiaochuan Ye Huabing Chen Huibi Xu Xiangliang Yang (Institute of Life Science and Technology,Department of Chemistry,Huazhong University of Science & Technology,Wuhan 430074,China

【机构】 华中科技大学生命科学与技术学院；

【摘要】 本文综述了本课题组近几年来关于雷公藤内酯醇纳米载药系统及雷公藤内酯醇体外代谢的研究工作,包括雷公藤内酯醇固体脂质纳米粒、微乳和聚合物纳米粒的制备、表征、药理、毒理及雷公藤内酯醇在大鼠肝微粒体中的代谢动力学等。结果表明雷公藤内酯醇纳米载药系统可维持较好的药效,降低其毒性;雷公藤内酯醇体外代谢符合Michaelis-Menten方程。更多还原

【Abstract】 The paper has mainly introduced the research work on triptolide-loaded nanoparticle delivery systems and metabolism process of triptolide in vitro in recent years.The preparation,characterization, pharmacology and toxicology of solid lipid nanoparticles,microemulsion and polymer nanoparticles as well as kinetics of metabolism process of triptolide in rat liver microsomes vitro have investigated in this paper. The results obtained have indicated that there are better drug-effect preserved and lower toxicity-side effect in triptolide-loaded nanoparticle delivery systems,and the metabolism of triptolid in various rat liver mi- crosomes followed Michaelis-Menton kinetics.更多还原