【作者】 黄赞松； 周喜汉； 覃月秋； 韦星；

【机构】 右江民族医学院消化疾病研究所； 右江民族医学院生物化学与分子生物学教研室；

【摘要】 <正>引言肝癌是我国常见的恶性肿瘤,死亡率高。在肝癌的非手术综合治疗中化疗占有重要地位,但传统化疗药物存在疗效低、不良反应大及耐药性增多等缺点。三氧化二砷是中国传统中药砒霜的主要有效成分,在治疗急性早幼粒性白血病中取得了显著疗效。近年来,As203在更多还原

【Abstract】 Objective:To study the effects of arsenic trioxide (As203) on inhibiting the proliferation of hepatocellular carcinoma cell lines BELL-7402 and HepG2. Methods:The human hepatoceilar carcinoma cell lines BELL-7402 and HepG2,ant the human normal liver cell line L-02 were treated with As203 in various concentration for various days,and then observed and analyzed by 3-(4,5-dimethylthiazole-2-yl)-2,5- diphenyitetrazolium bromide(M TT) assay,to detect the inhibitory rate of As203 and other anticancer drugs (Oxaliplation and 5-Fu). Results:As compared with other 2 kinds of anticancer drugs,the inhibition of As203 was the most obvious(P <0.05).The inhibition of As203 in the groups with the concentration above 5.0 μmol/L were of no difference (P >0.05),but the inhibition was not obvious for L-02 cell. Conclusions:As203 has obvious antitumor activity on hepatocellular carcinoma cell lines,and the inhibitory rate was dependent on As203 concentration and treatment time.更多还原