【作者】 郑广娟； 王苓； 张丹； 张静； 夏丽英；

【Author】 ZHENG guang-juan , WANG ling , ZHANG dan , ZHANG jing , XIA li-yingDepartment of pathology , Shandong medical universityof traditional medicine , Jinan (250014)

【机构】 山东中医药大学病理教研室；

【摘要】 <正> 前言脑缺血是脑血管病致残和死亡的主要原因之一。多年来一直是临床治疗的难点和科研的重点。尤其是脑缺血导致的脑组织水肿程度是指导临床用药和判断预后的关键。以往的研究对脑组织水肿程度的判断量化方法粗浅且用药种类多,作用单一,从而影响了临床疗效和预后的判断。针对以上两个问题。我们选择了临床疗效肯定的中药复方,脑脉通对急性不完全性脑缺血模型脑间质水肿程度的多个指标用包括图像分析在内方法进行了半定量研究,并对作用机理进行探讨。更多还原

【Abstract】 In this study, incomplete cerebral ischemia models which were established by the ligature of bilateral common carotid artery , were randomly divided into six groups: sham - operated group, operation group, large dosage Naomaitong group , medium dosage Naomaitong group, small dosage Naomaitong group and Weinaotong group . After the administration of medicines , cerebral water containing , brain index, capillary permeability, the edema level of cerebral interstitium were observed and pericellular space of brain was assayed by image analyzer. The result showed that , in comparison with operation group, cerebral water containing, brain index and capillary permeability were apparently higher in sham - operated group. In comparison with sham - operated group, cerebral water containing , brain index and capillary permeability were apparently lower in large dosage Naomaitong group, medium dosage Naomaitong group, small dosage Naomaitong group and Weinaotong group, and with histological morphological observation, the above - mentioned four groups were unapparent for edema level of cerebral interstitium and pericellular space of brain. The above result suggests that Naomaitong has the effect of anti - encephaledema to prevent cerebral hernia in incomplete cerebral ischemia.更多还原