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寻常型银屑病患者皮损中维A酸受体(RAR γ/RXR α)mRNA的表达(英文)

Expression of RAR y /RXR a mRNA in Patients with Psoriasis Vulgaris

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【作者】 冯素英林麟吴勤学周武庆

【Author】 Feng Suying, Linlin, Wu Qinxue, Zhou Wuqin.Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042

【机构】 中国医学科学院中国协和医科大学皮肤病研究所

【摘要】 <正> Objective To study the level of the expression of RAR y /RXR a mRNA in the skin lesions of patients with psoriasis vulgaris. Methods The epidermic biopsies from psoriatic lesions in 20 cases with psoriasis vulgaris and 10 normal controls were investigated with RT-PCR. Results The level of RXR a mRNA were markedly lower in epidermis from patients with psoriasis vulgaris than those from control. These was not statistical significance in the level of the expression of RAR a mRNA between patients with psoriasis vulgaris and normal controls (P>0.05). Conclusion The results indicate that decreased level of expression of RXR a mRNA might be related to the pathogenesis of psoriasis.

【Abstract】 Objective To study the level of the expression of RAR y /RXR a mRNA in the skin lesions of patients with psoriasis vulgaris. Methods The epidermic biopsies from psoriatic lesions in 20 cases with psoriasis vulgaris and 10 normal controls were investigated with RT-PCR. Results The level of RXR a mRNA were markedly lower in epidermis from patients with psoriasis vulgaris than those from control. These was not statistical significance in the level of the expression of RAR a mRNA between patients with psoriasis vulgaris and normal controls (P>0.05). Conclusion The results indicate that decreased level of expression of RXR a mRNA might be related to the pathogenesis of psoriasis.

【Key words】 Rtinoids Receptor psoriasis
  • 【会议录名称】 2002中国中西医结合皮肤性病学术会议论文汇编
  • 【会议名称】2002中国中西医结合皮肤性病学术会议
  • 【会议时间】2002-03
  • 【会议地点】中国苏州
  • 【分类号】R758.63
  • 【主办单位】中国中西医结合学会皮肤性病专业委员会
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