【作者】 冯素英； 林麟； 吴勤学； 周武庆；

【Author】 Feng Suying, Linlin, Wu Qinxue, Zhou Wuqin.Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042

【机构】 中国医学科学院； 中国协和医科大学皮肤病研究所；

【摘要】 <正> Objective To study the level of the expression of RAR y /RXR a mRNA in the skin lesions of patients with psoriasis vulgaris. Methods The epidermic biopsies from psoriatic lesions in 20 cases with psoriasis vulgaris and 10 normal controls were investigated with RT-PCR. Results The level of RXR a mRNA were markedly lower in epidermis from patients with psoriasis vulgaris than those from control. These was not statistical significance in the level of the expression of RAR a mRNA between patients with psoriasis vulgaris and normal controls (P>0.05). Conclusion The results indicate that decreased level of expression of RXR a mRNA might be related to the pathogenesis of psoriasis.更多还原

【Abstract】 Objective To study the level of the expression of RAR y /RXR a mRNA in the skin lesions of patients with psoriasis vulgaris. Methods The epidermic biopsies from psoriatic lesions in 20 cases with psoriasis vulgaris and 10 normal controls were investigated with RT-PCR. Results The level of RXR a mRNA were markedly lower in epidermis from patients with psoriasis vulgaris than those from control. These was not statistical significance in the level of the expression of RAR a mRNA between patients with psoriasis vulgaris and normal controls (P>0.05). Conclusion The results indicate that decreased level of expression of RXR a mRNA might be related to the pathogenesis of psoriasis.更多还原