【作者】 颜文飞； 郑敏； 孙国钧；

【Author】 YAN Wenfei, ZHENG Min, SUN Guojun, Department of Dermatology,Second Affiliated Hospital, Medical college of Zhejiang University.Hangzhou 310009

【机构】 浙江大学医学院附属二院皮肤科；

【摘要】 目的 探讨角质形成细胞生长因子（KGF）及神经细胞生长因子（NGF）和银屑病的关系。 方法 应用免疫组织化学技术分别检测了33例银屑病患者、 8例非皮损组皮肤和13例正常人皮肤组织中的KGF、KGFR、NGF和P75NGFR的蛋白表达。 结果 KGF、KGFR主要表达在银屑病患者皮肤的基底层和基底上层;NGF、NGFR则主要表达在颗粒层和棘细胞上层,真皮浅层的淋巴样细胞也有较高的表达。与非皮损组及正常对照相比,各因子在银屑病皮损中的表达强度均显著上调（p<0.05）。 结论 KGF、NGF对银屑病表皮中的角质形成细胞的增生、分化均有重要的作用,而NGF还可以介导炎症反应及免疫反应。更多还原

【Abstract】 Objective To study the relationship between Keratinocyte Growth Factor, Nerve Growth Factor and psoriasis. Methods The skin biopsies from psoriasis lesion in 33 cases with psoriasis, 8 non-lesional and 13 normal controls were investigated by immunohistochemical technique. Results The expressions of KGF and KGFR protein were localized on the basal and lower spinous layers adjacent to the basal cell, while NGF and NGFR were observed mainly throughout the whole epidermis except the basal layers and lower spinous layers. There was significant difference of their expressions between the normal controls, non-lesional and psoriatic groups (p<0.05). Conclusion KGF and NGF may play an important role in the hyperplasia and differentiation of keratinocyte in psoriasis; NGF also mediate inflammatory and immunity reaction.更多还原