【作者】 向兰； 郭东晓； 鞠瑞； 马彬； 雷帆； 杜力军；

【Author】 Xiang Lan, Guo Dongxiao, Ju Rui, Ma Bing, Lei Fan, Du Lijun School of Pharmacy, Shandong University, Jinan, 250012 Department of Biological Science and Biotechnology, Tsinghua University, Beijing, 100084

【机构】 山东大学药学院； 清华大学生物技术与科学系；

【摘要】 目的:对马齿苋的化学成分进行研究。方法:利用柱色谱方法分离化合物,根据核磁共振光谱等数据进行化合物结构鉴定。结果:从马齿苋70%乙醇提取物中分离鉴定了6个化合物,分别为丁二酸(琥珀酸)(1)、 6,7-二羟基香豆素(2)、3-异丁基-6-甲基哌嗪-2,5-二酮(3)、3-仲丁基-6-甲基哌嗪-2,5-二酮(4)、3-(4- 羟基苄基)-6-苄基哌嗪-2,5-二酮(5)和马齿苋酰胺A(6)。结论:化合物2、3、4和5为首次从马齿苋中分离得到,为进一步研究马齿苋的活性成分及新药开发提供了基础。更多还原

【Abstract】 Objective: Research on chemical constituents of Portulaca oleracea L.. Method: The constituents were isolated by various column chromatography and their structures were identified on the basis of one and two dimensional NMR spectral data. Results: Six compounds were isolated and identified as butanedioic acid(1), 6,7-dihydroxycoumarin(2),3-isobutyl-6-methylpiperazine-2,5-dione (3) and 3-sec-butyl-6-methylpiperazine-2,5-dione (4), 3-(4-hydroxybenzyl)-6-benzylpiperazine-2,5- dione(5) and oleracein A(6). Conclusion: Compounds 2, 3, 4 and 5 were firstly isolated from Portulaca oleracea L., which will benefit for further research on bioactive constituents as well as new drug exploitation.更多还原