【作者】 王蔚青； 张宏文； 王永庆； 邵志高； 顾文凯；

【Author】 Wang Weiqing Zhang Hongwen Wang Yongqing Shao Zhigao Gu Wenkai First Affiliated Hospital of Nanjing Medical University (Nanjing 210029)

【机构】 南京医科大学第一附属医院；

【摘要】 目的对地高辛给药的患者进行治疗监测及临床作用因素分析。方法对91例使用地高辛的患者进行住院病例分析。结果地高辛血药浓度大于2.0ng·ml^-1的患者有9例,血药浓度低于0.5ng·ml^-1的患者有15例,它们分别占总病例数的9.9%和16.5%。ECG（心电图）检查显示房室传导阻滞占9.9%,室性早搏占19.8%,房颤占29.7%。结论地高辛血药浓度大于2.0ng·ml^-1或浓度小于0.5ng·ml^-1是多种因素共同影响的结果,包括合并用药,肾功能损害等因素。对地高辛血药浓度监测,应与临床症状相结合,才能得出是否用药过量或不足的结论。更多还原

【Abstract】 Objective To study the therapeutic effects and clinical correlation factors of Digoxin in CHF patients.Methods 91 cases of in-patients administrated with Digoxin was analyzed.Results The patients,whose serum concentration of Digoxin were more than 2.0ng.ml^-1 or less than 0.5ng.ml^-1,accounted for 9.9% or 16.5% of total studied.The atrioventricular block proved by ECG accounted for 9.9%,the ventricular contraction for 19.8% and the atrial fibrillation for 29.7%. Conclusion the concentration of Digoxin is more than 2.0ng.ml^-1 or less than 0.5ng.ml^-1 is induced by multi-factors including drug combination,kidney injury,and so on.The therapeutic drug monitoring of Digoxin should be made in combination with the clinical symptoms.更多还原