【作者】 邹毅； 刘之光； 杨芳炬； 范科华； 李东；

【Author】 Zou Yi Liu Zhiguang Yang Fangju Fan Kehua Li Dong (West China School of Preclinical and Forensic Medicine,Sichuan University,Chengdu 610041)

【机构】 四川大学基础与法医学院；

【摘要】 目的：研究十五味黑药丸对大鼠胃肠运动的影响。方法：以胃肠道标记物葡聚糖蓝2000的胃内相对残留率和小肠推进率为指标,观察十五味黑药丸对大鼠胃排空及小肠推进运动的影响；通过生物信号采集与处理系统记录大鼠胃纵形肌条张力参数,观察该药对胃条张力的影响。结果：十五味黑药丸能明显降低葡聚糖蓝2000的胃内相对残留率及增加其小肠推进率,十五味黑药丸药液能明显增加胃条张力。结论：十五味黑药丸能促进胃肠运动。更多还原

【Abstract】 Objective:To study the effects of Shiwuwei Heiyaowan (SH) on gastrointestinal motility in rats.Methods:The relative residual rate of Dextran blue-2000 (DB) in stomach and the small intestinal transit rate of DB were determined to evaluate SH’s effects on gastric emptying and small intestinal transit in rats;the contraction intensity of isolated stomach strip of the rat was measured to evaluate SH’s effect on the con- traction intensity of stomach.Results:SH administration at a dose of 1.0g/kg or 2.0g/kg significantly reduced the relative residual rate of DB in stomach and raised the small intestinal transit rate of DB (1.0g/kg,P＜0.05;2.0g/kg,P＜0.01);the physic liquor of SH at a concentration of 1.0g/kg or 2.0g/kg significantly increased the contraction intensity of isolated stomach strip (1.0g/kg,P＜0.05;2.0g/kg, P＜0.01).Conclusion:FFBP can promote gastrointestinal motility in rats.更多还原