【作者】 杨桂枝； 赵佳； 田汉文； 杨琴； 王蕾； 马玉群；

【Author】 Yang Guizhi Zhao Jia Tian Hanwen Yang Qin Ma Yuqiong (Dep.of Histology and Embryology,Sichuan University,Chendu 610041)

【机构】 四川大学基础医学与法医学院；

【摘要】 目的：研究雷公藤多甙(TWH)对佐剂性关节炎(Adjuvant Arthritis,AA)模型大鼠 L6背根节血管活性肠肽(vasosc- tive intestinal peptide,VIP)的影响。方法：用完全弗氏佐剂(FCA)诱导大鼠形成关节炎,经 TWH 预防和治疗处理后,观察大鼠足趾关节炎症指数、踝关节滑膜病理改变,并检测 L6背根节 VIP 表达的变化。结果：TWH 预防组能阻止大鼠继发性病变的发生,而治疗组能显著减轻大鼠足趾关节肿胀、关节炎症指数,减轻踝关节滑膜病理改变。同时 TWH 预防组和治疗组均能显著上调 L6背根节 VIP 表达。结论：TWH 能改善 AA 大鼠关节炎症状、抑制炎症反应,预防继发性病变的发生,其作用机理可能通过上调背根节 VIP 的表达有关。更多还原

【Abstract】 Objective:To investigate the effects of Tripterygium wilfordii Hook (TWH) on vasoactive intestinal peptide (VIP) expression of L6 dorsal root ganglia in model rats with adjuvant arthritis (AA).Methods:The rats were immunized with the Freund’s Complete Adjuvant (FCA),after protected or treated with TWH,the pathomorphological changes of synovium and the arthritis index (AI) were examined,and expression of VIP of L6 dorsal root ganglia were also assayed.Results:Compared with model control,TWH can prevent the secondary arthri- tis of rats.the AI was markedly deceased and the pathomorphological changes of synovium were significantly improved after TWH treatment. The expression of VIP in dorsal root ganglia was increased in TWH protected or treated rats.Conclusion:TWH can prevent the secondary ar- thritis,improve the pathomorphological changes of AA rats,the mechanism might be associated to its up-regulation of VIP in L6 dorsal root ganglia.更多还原