【作者】 王惠； 于丽秋； 韩冰； 滕佳林； 贾建昌；

【Author】 Wang Hui Yu Liqiu Han Bing Teng Jialin Jia Jianchang (The Tumour Laboratory in Shandong University of Traditional Chinese Medicine,Jinan 250014)

【机构】 山东中医药大学肿瘤实验室；

【摘要】 目的：探讨黄芪配伍当归(QG)对气虚血瘀模型大鼠心肺血管内皮和肝窦内皮细胞 CD54表达的影响。方法：用饥饿+游泳制造“气虚血瘀”大鼠模型,灌胃给药15d 后测定心肺血管内皮和肝窦内皮细胞 CD54的表达。结果：气虚血瘀模型大鼠心肺血管内皮和肝窦内皮细胞 CD54的表达明显增高,QG 能显著降低其过度表达。结论：QG 益气活血作用与降低心肺血管内皮和肝窦内皮细胞 CD54的过度表达有关。更多还原

【Abstract】 Objective:To investigate the influence of Astragalus membranaceus combined with Angelica sinensis (QG for short) on the expression of CD54 in vessels endothelial ceils(VECs) and hepatic sinusoid endothelial cells(HSECs) of Qi-Deficiency and Blood-Stasis model rats. Methods:Using the method of hunger and fatigue to establish Qi-Deficiency and Blood-Stasis model rats,measuring the expression of CD54 in VECs and HSECs after ig administrate for 15d.Results:The expression of CD54 in VECs and HSECs of Qi-Deficiency and Blood -Stasis model rats markably raised,QG can effectively decrease their excessive expression.Conclusion:Inhibiting the excessive expression of CD54 in VECs and HSECs may be one of the molecular mechanism of Replenishing Qi and Promoting Blood Circulation of QG.更多还原